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September 10, 2025Open Access

Molecular docking analysis of Naringenin from the leaves of Psidium guajava as a promising agent for breast cancer therapy

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Authors

MVMurugesan VijiSJSasireigga Jaya JothiKYKrishnamoorthy Yasiha

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Overview

This analysis reveals naringenin's binding properties to breast cancer proteins, suggesting promising anticancer effects.

Key Points

  • Naringenin demonstrated strong binding affinities to breast cancer targets, indicating potential therapeutic effects.
  • Molecular docking identified the highest binding scores to catalase, CDK4, and CDK6, suggesting effective interactions.
  • Naringenin passed Lipinski’s Rule of Five, showing favorable drug-likeness and good oral bioavailability.
  • Hydrogen bond interactions with multiple proteins highlight naringenin’s role in modulating oxidative stress pathways.

Cite This Study

Viji et al. (2025) studied this question.

synapsesocial.com/papers/68c23caeb210217d6478aa1fhttps://doi.org/10.64659/jomi/210351
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Also Consider

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  1. 1Naringenin Inhibits Cellular Proliferation, Arrests Cell Cycle and Induces Pro‐Apoptotic Autophagy in <scp>MCF</scp>‐7 Breast Cancer Cells2025 · 9 citations
  2. 2Naringenin nanoparticles show anti-angiogenic activity in HUVECs and a chick chorioallantoic membrane model and anticancer activity in MCF-7 cells2025 · 1 citations
  3. 3Value Addition to Citrus maxima Peels: Extraction and Modification of Naringenin into Hydrazones Derivatives for Anti-Breast Cancer and Osteogenic Activity via In Vitro and In Silico Studies.2025
  4. 4Naringin from Citrus maxima peel: a potential therapeutic agent for breast cancer via PKM2 inhibition2025 · 1 citations
  5. 5Quercetin and Its Structural Analogs as NUDT5 Inhibitors: A Preliminary In Silico Study2025