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September 10, 2025Open Access

Molecular docking analysis of Naringenin from the leaves of Psidium guajava as a promising agent for breast cancer therapy

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Authors

MVMurugesan VijiSJSasireigga Jaya JothiKYKrishnamoorthy Yasiha

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Overview

This analysis reveals naringenin's binding properties to breast cancer proteins, suggesting promising anticancer effects.

Key Points

  • Naringenin demonstrated strong binding affinities to breast cancer targets, indicating potential therapeutic effects.
  • Molecular docking identified the highest binding scores to catalase, CDK4, and CDK6, suggesting effective interactions.
  • Naringenin passed Lipinski’s Rule of Five, showing favorable drug-likeness and good oral bioavailability.
  • Hydrogen bond interactions with multiple proteins highlight naringenin’s role in modulating oxidative stress pathways.

Cite This Study

Viji et al. (2025) studied this question.

synapsesocial.com/papers/68c23caeb210217d6478aa1fhttps://doi.org/10.64659/jomi/210351
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