September 10, 2025Biochemical and Biophysical Research CommunicationsOpen Access

Maladaptive role of peridroplet mitochondria during lipophagy disruption in pancreatic cancer

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Authors

ZZZhiheng Zhang LFLiye FangUniversity of Alberta HFH Furukawa

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Observational analysis reveals impaired mitochondrial respiration in pancreatic cancer cells, indicating maladaptive peridroplet mitochondria under lipid stress.

Key Points

Disrupted lipophagy leads to lipid droplet accumulation and impaired mitochondrial respiration.
SP-2509 treatment increased peridroplet mitochondria but did not enhance fatty acid oxidation.
Mitochondrial relocation correlates with reduced cell viability under lipid overload.
Maladaptive peridroplet mitochondria may represent a new therapeutic target in pancreatic cancer.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c23caeb210217d6478a49e https://doi.org/10.1016/j.bbrc.2025.152609

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Implication

Observational analysis reveals impaired mitochondrial respiration in pancreatic cancer cells, indicating maladaptive peridroplet mitochondria under lipid stress.

Maladaptive role of peridroplet mitochondria during lipophagy disruption in pancreatic cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Maladaptive role of peridroplet mitochondria during lipophagy disruption in pancreatic cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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