Straightforward Access to Terpene-Based 1,2-Diols and Their Acetals as Fragrance Ingredients

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Analysis reveals effective conversion of sesquiterpene to 1,2-diols, suggesting improved fragrance production.

The methodology achieved up to 76% yield of cis-cedrane-8,9-diol, enhancing fragrance synthesis efficiency.
Potassium permanganate was identified as the most effective reagent for cis-dihydroxylation of terpenes.
The resulting 1,2-diols were converted to acetonides with yields reaching 92%, offering potent aromatic properties.
Additional terpene substrates yielded corresponding 1,2-diols at rates up to 83%, indicating broad applicability.

Stefanow et al. (2025) studied this question.

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