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September 10, 2025Open Access

An Inflammatory and Quiescent HSC Subpopulation Expands with Age in Humans

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Authors

KSKsenia R. SafinaDKDylan KotliarMCMichael J. Curtis

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Overview

Analysis uncovers age-related changes in gene expression of hematopoietic stem cells, suggesting inflammatory pathways play a crucial role.

Key Points

  • An inflammatory HSC subpopulation increases with age, highlighting its relevance in aging-related health issues.
  • Consensus mapping of gene expression revealed significant heterogeneity in HSCs, emphasizing their complex nature.
  • Activation of inflammatory pathways such as TNF/NFκB links to cellular quiescence, suggesting a unified program in HSC aging.
  • The findings point to potential targets for experimental studies and interventions aimed at countering aging effects.

Cite This Study

Safina et al. (2025) studied this question.

synapsesocial.com/papers/68c23caeb210217d6478a097https://doi.org/10.1101/2025.09.01.673389
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