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September 10, 2025World Journal of Gastroenterology

Natural killer cell-based immunotherapies for colorectal cancer: Current strategies, challenges, and future perspectives

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Authors

XZXiaojun ZhangYYYan YuJLJingyu Li

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Overview

This review evaluates NK cell immunotherapy for colorectal cancer, highlighting challenges and innovative strategies that may enhance effectiveness.

Key Points

  • Natural killer cells can effectively eliminate colorectal cancer cells, offering a novel therapeutic avenue.
  • NK cell-based strategies such as cytokine therapy and adoptive cell transfer show clinical promise, despite limitations.
  • Expansion and engineering of NK cells face significant challenges, along with the suppressive tumor microenvironment.
  • Emerging strategies, including combination therapies and personalized medicine, aim to enhance NK cell therapy outcomes.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c23caeb210217d6478a01ehttps://doi.org/10.3748/wjg.v31.i34.110051
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Recent advances in tumor immunotherapy based on NK cells2025
  2. 2Nanotechnology and natural killer cell immunotherapy: synergistic approaches for precise immune system adjustment and targeted cancer treatment in gastrointestinal tumors2025
  3. 3Natural Killer Cells Therapy: From in Vitro Amplification to Engineering Modification2025
  4. 4Natural Killer Cell‐Mediated Antitumor Immunity: Molecular Mechanisms and Clinical Applications2025 · 5 citations
  5. 5Engineered NK Cells: A Breakthrough Strategy to Overcome Cancer Immunosuppression2025