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September 10, 2025Open Access

BioML-bench: Evaluation of AI Agents for End-to-End Biomedical ML

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Authors

HMHenry E. MillerMGMatthew GreenigBTBenjamin Tenmann

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Overview

Benchmark evaluates AI agents on diverse biomedical ML tasks, highlighting performance gaps and potentials.

Key Points

  • Agents showed lower performance compared to human baselines in biomedical ML tasks, indicating limitations.
  • On average, agents that employed diverse ML strategies achieved higher scores, suggesting architecture influences success.
  • BioML-bench is the first comprehensive suite for assessing AI in end-to-end biomedical ML workflows across four domains.
  • Findings underscore the need for systematic approaches to evaluate AI agents, reflecting current limitations in biomedical applications.

Cite This Study

Miller et al. (2025) studied this question.

synapsesocial.com/papers/68c23caeb210217d64789dcchttps://doi.org/10.1101/2025.09.01.673319
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Also Consider

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  1. 1MedAgentBench: A Virtual EHR Environment to Benchmark Medical LLM Agents2025
  2. 2BioLab: End-to-End Autonomous Life Sciences Research with Multi-Agents System Integrating Biological Foundation Models2025
  3. 3Large Language Model Agents for Biomedicine: A Comprehensive Review of Methods, Evaluations, Challenges, and Future Directions2025
  4. 4AI Agents in Clinical Medicine: A Systematic Review2025 · 36 citations
  5. 5MedAgentGym: A Scalable Agentic Training Environment for Code-Centric Reasoning in Biomedical Data Science2025