This review demonstrates how spatially resolved transcriptomics impacts tumor microenvironment heterogeneity, highlighting therapeutic efficacy in cancer immunotherapy.
Key Points
The tumor microenvironment significantly influences the effectiveness of cancer immunotherapy, affecting patient outcomes and resistance.
Spatially resolved transcriptomics allows for detailed gene expression analysis with spatial context, enhancing understanding of tumor heterogeneity.
The review systematically introduces various SRT strategies, weighing their pros and cons in profiling the tumor microenvironment.
Insights gained from SRT can lead to novel therapeutic targets and improved biomarker discovery for personalized cancer treatment.