Synovial changes in osteoarthritis: symptom or disease driver?

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This review highlights how synovial changes may drive osteoarthritis progression, suggesting new treatment targets.

Synovial changes may actively drive osteoarthritis progression, contrary to traditional views.
Evidence shows pathological remodeling in the synovium relates to both pain and joint degeneration.
This review employs a comprehensive approach, detailing mechanisms involving synoviocytes and macrophages.
Understanding these mechanisms could inform new therapeutic strategies for osteoarthritis management.

Miller et al. (2025) studied this question.

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