September 10, 2025Open Access

Sex differences in the developing human cortex intersect with genetic risk of neurodevelopmental disorders

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This analysis reveals genetic risk factors and sex-based disparities in neurodevelopmental disorders.

A significant finding shows that risk genes for neurodevelopmental disorders are more expressed in females, particularly MEF2C.
Data from 27 males and 21 females reveal two main vulnerabilities contributing to sex-biased penetrance of neurodevelopmental disorders.
The study uses transcriptomic and epigenomic profiles to analyze sex differences in the developing human cortex.
These insights highlight the role of the X chromosome in the development of sex differences and vulnerability to neurodevelopmental disorders.

Hennick et al. (2025) studied this question.

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