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September 10, 2025Science AdvancesOpen Access

Microenvironment-driven transformable self-assembly nanoplatform enables spatiotemporal remodeling for rheumatoid arthritis therapy

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Authors

CHChuan HuJMJiaqi MaXCXi Chen

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Overview

This approach shows improved drug delivery and vasculature repair in rheumatoid arthritis, suggesting better therapy outcomes.

Key Points

  • The nanoplatform efficiently delivers drugs to the inflamed joint cavity, addressing a key challenge in rheumatoid arthritis treatment.
  • The strategy achieved rapid vasculature repair and sustained normalization, improving therapeutic delivery in rheumatoid arthritis.
  • Transformable nanofibers act as a barrier, promoting both short-term and long-term improvements in joint pathology.
  • Charge reversal and RGD exposure of nanoparticles enable targeted delivery of triptolide and metformin for RA management.

Cite This Study

Hu et al. (2025) studied this question.

synapsesocial.com/papers/68c23c20b210217d64787debhttps://doi.org/10.1126/sciadv.adu5245
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