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September 10, 2025Current Respiratory Medicine Reviews

Emerging Therapeutic Approaches to Drug-Resistant Tuberculosis: Compressive Review

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Authors

VKVenkatesan KarthickNVN VenkateswaramurthyPDP. Dineshkumar

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Overview

This review highlights therapeutic improvements in drug-resistant TB, demonstrating better outcomes with novel agents like bedaquiline and delamanid.

Key Points

  • Therapeutic advancements have led to success rates of 73-90%, versus 50-60% for conventional treatments.
  • Analysis of 125 studies revealed that the BPaL regimen shows 89-90% favorable outcomes in just 6 months.
  • Recent trials indicate rising bedaquiline resistance, increasing to 5.7% globally.
  • Novel agents like delamanid achieve a 73.1% success rate with notable culture conversion rates.

Cite This Study

Karthick et al. (2025) studied this question.

synapsesocial.com/papers/68c23c20b210217d64787725https://doi.org/10.2174/011573398x409282250823051901
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