September 10, 2025Frontiers in PediatricsOpen Access

Successful sequential therapy for Stenotrophomonas maltophilia infection in a preterm neonate: a case report

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Discussion

Case report shows sequential therapy improves clinical outcomes in a neonate with sepsis, indicating tailored antimicrobial strategies.

Sequential therapy with trimethoprim-sulfamethoxazole and levofloxacin resolved the infection in the preterm neonate.
Following ineffective initial treatment, switching to levofloxacin led to clinical recovery and infection clearance.
The approach underlines the need for customized antimicrobial strategies to tackle multidrug-resistant infections.
This case emphasizes the importance of judicious use of fluoroquinolones in resistant S. maltophilia cases.

Nahari et al. (2025) studied this question.

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