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September 10, 2025Archive of Biomedical Science and EngineeringOpen Access

Fluorophenyl-1,2,4-Triazole Derivatives: Synthesis, Structural Analysis, Chemotype Clustering and Antimicrobial Screening

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Authors

CUCebeci Yıldız UygunBÖBatur Özge Özşen

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Overview

Synthesis and structural analysis of fluorophenyl-1,2,4-triazole derivatives showed promising antimicrobial activity in bacteria, highlighting chemotype clustering implications.

Key Points

  • Compounds 6a–6f exhibited significant antimicrobial potency, with MIC values as low as 6.25 µg/mL against E. coli and S. aureus.
  • Key transformations including hydrazinolysis and cyclization were involved in the synthesis and structural elucidation of the derivatives.
  • Chemotype clustering provided insights into the relationship between structural modifications and antimicrobial efficacy.
  • The most active compounds showed promising antibacterial activity comparable to standard antibiotics like tetracycline.

Cite This Study

Uygun et al. (2025) studied this question.

synapsesocial.com/papers/68c23bd7b210217d64787364https://doi.org/10.17352/abse.000036
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