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September 10, 2025DNAOpen Access

Mutational Characterization of Astrocytoma, IDH-Mutant, CNS WHO Grade III in the AACR GENIE Database

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Authors

ETElijah TorbensonBHBeau HsiaNLNigel Lang

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Overview

Observational analysis identified somatic mutations and molecular features in astrocytoma IDH-mutant, suggesting pathways for targeted therapies.

Key Points

  • The most common mutations in astrocytoma IDH-mutant were in IDH1, TP53, and ATRX.
  • Somatic mutation frequencies included IDH1 (98%), TP53 (94.8%), and ATRX (55.2%), highlighting significant mutational patterns.
  • Analysis of the AACR GENIE database revealed frequencies of copy number alterations and structural variants in this tumor type.
  • These results support the need for continued genomic integration to enhance prognostic and therapeutic strategies.

Cite This Study

Torbenson et al. (2025) studied this question.

synapsesocial.com/papers/68c23bd7b210217d64786cabhttps://doi.org/10.3390/dna5030043
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1EP12.14 ASTROCYTOMA IDH-MUTANT WITH PRIMITIVE NEURONAL COMPONENT2025
  2. 2OS09.5.A RECURRENT COPY NUMBER ALTERATIONS DRIVE IDH-MUTANT ASTROCYTOMA DEVELOPMENT AND PROGRESSION2025
  3. 3Tumor-initiating genetics and therapy drive divergent molecular evolution in IDH-mutant gliomas2025 · 4 citations
  4. 4Protein-based classification reveals an immune-hot subtype in IDH mutant astrocytoma with worse prognosis2025 · 20 citations
  5. 5Next-Generation Sequencing Reveals a Diagnostic and Prognostic Role of the TP53 R273C Mutation in Lower-Grade, IDH-Mutant Astrocytomas2025