The In Vitro Toxicity Profile of Nanoencapsulated Curcumin in a Chitosan–Alginate Gel Carrier Using Rabbit Lymphocytes: Preliminary Research

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This in vitro study shows that nanoencapsulated curcumin decreases cell viability in rabbit lymphocytes, indicating potential toxicity.

Nanoencapsulated curcumin significantly reduced blood cell viability to about 1-9%, revealing cytotoxic effects.
In vitro tests demonstrated that curcumin formulations were toxic across all concentrations, with significant results.
Cell damage was identified using the micronucleus and comet assays, detecting escape of apoptotic cells after exposure.
Repeated research is necessary as variability was observed across different concentrations and matrix forms of curcumin.

Kuchta‐Gładysz et al. (2025) studied this question.

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