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September 10, 2025Schizophrenia Bulletin OpenOpen Access

Obstacles, opportunities, and ethical considerations for genomic investigations of individuals continuously hospitalized with treatment-resistant schizophrenia

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Authors

RJRichard C. JosiassenRXRose Mary XavierTDTyler E Dietterich

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Overview

This article reviews ethical challenges of genomic investigations in treatment-resistant schizophrenia, suggesting possible solutions for inclusion. It highlights the importance of informed consent and cognitive capacity evaluation.

Key Points

  • Carefully selected involuntarily committed individuals can participate in genomic research, enhancing knowledge of treatment-resistant schizophrenia.
  • Cognitive impairment is a greater barrier to decision-making capacity than the severity of psychopathology, impacting informed consent.
  • Ethical safeguards can effectively address concerns around consent in research involving individuals with severe mental illness.
  • Health care disparities may be perpetuated by excluding involuntarily hospitalized patients from essential research.

Cite This Study

Josiassen et al. (2025) studied this question.

synapsesocial.com/papers/68c23bd7b210217d64786acfhttps://doi.org/10.1093/schizbullopen/sgaf019
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