This study demonstrates transcriptional dysregulation in cardiac neurons linked to cognitive impairments in congenital heart disease, highlighting systemic neurodevelopmental risks.
Key Points
Cardiac neurons in congenital heart disease show significant transcriptional dysregulation associated with cognitive impairments.
The analysis revealed enriched expression of genes linked to neurodevelopmental disorders, including NRXN3 and BDNF.
Single-nucleus RNA-sequencing data from over 157,000 cardiac nuclei provided detailed insights into neuronal populations.
These findings suggest intercellular communication mechanisms that link cardiac pathology to neurodevelopment.