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September 10, 2025AIDS

Predicting risk of cardiovascular events (PREVENT) score accuracy among people with HIV in the multicenter CNICS cohort

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Authors

MDMatthew S. DurstenfeldRNRobin M. NanceRJRaymond C. F. Jones

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Overview

Observational analysis assessed cardiovascular risk using PREVENT and PCE in individuals with HIV, suggesting potential underestimation of risk.

Key Points

  • PREVENT underestimated risk for myocardial infarction and stroke compared to observed rates among individuals with HIV.
  • Mean predicted 10-year ASCVD risk was 2.9% for PREVENT and 5.8% for PCE, with both underpredicting actual outcomes.
  • Discrimination between the two prediction equations improved with PREVENT showing a C-index of 0.722 versus 0.708 for PCE.
  • Calibration results showed significant discrepancies, with PREVENT having a calibration slope of 1.998 and PCE at 0.932.

Cite This Study

Durstenfeld et al. (2025) studied this question.

synapsesocial.com/papers/68c23bd7b210217d64786566https://doi.org/10.1097/qad.0000000000004331
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