Diagnostic values of TPT1 in patients with sepsis, septic shock and in non-infected controls: A single-center prospective observational cohort study in ICU patients

Objective To evaluate the diagnostic value of tumor protein translationally-controlled 1 (TPT1) in patients with sepsis and septic shock in the intensive care unit (ICU). Methods This single-center, prospectively planned observational study included 53 ICU patients with sepsis (30 with non-shock sepsis, 23 with septic shock) and 20 non-infected ICU controls. Plasma levels of TPT1, procalcitonin (PCT), and C-reactive protein (CRP) were measured on day 1 of ICU admission. Diagnostic performance was assessed using receiver operating characteristic (ROC) analysis. Results TPT1 levels were associated with higher SOFA scores and serum creatinine levels ( p < 0.01). TPT1 levels were consistently significantly higher in non-shock sepsis and septic shock patients than in non-infected controls ( p < 0.001). On day 1, plasma TPT1 levels effectively differentiated non-shock from septic shock ( p < 0.01). TPT1 has good diagnostic value for sepsis and septic shock (AUC 0.80 and 0.94, respectively, p < 0.0001). TPT1 levels were significantly elevated in both non-shock sepsis and septic shock groups compared to non-infected controls ( p < 0.001). TPT1 also showed a positive correlation with SOFA score and serum creatinine ( p < 0.01). The area under the ROC curve (AUC) for TPT1 was 0.80 for sepsis and 0.94 for septic shock ( p < 0.0001), indicating moderate to high diagnostic accuracy. TPT1 outperformed CRP and PCT in distinguishing septic shock from non-shock sepsis (AUC = 0.71). Conclusions TPT1 has significant value as a diagnostic marker in sepsis and septic shock, with diagnostic capabilities comparable to procalcitonin and C-reactive protein.