September 10, 2025Clinical MedicineOpen Access

Challenges in the Diagnosis of Systemic Lupus Erythematosus

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Delayed diagnosis of systemic lupus erythematosus can lead to irreversible organ damage and increased mortality risk.
Reported time from symptom onset to diagnosis can be as long as 6 years, complicating patient outcomes.
The diagnosis of SLE relies on a combination of clinical and immunological features, which can vary widely.
General physicians and rheumatologists face challenges in recognizing SLE due to diagnostic test limitations and disease mimickers.

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Review outlines diagnostic challenges in systemic lupus erythematosus, highlighting clinical features and mortality risks.

Scopes et al. (2025) studied this question.

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