Quantification of Lung Ventilation Using Four‐Dimensional Dynamic Ultrashort Echo Time MRI for Differentiating Preserved Ratio Impaired Spirometry From Non‐Chronic Obstructive Pulmonary Disease Subjects

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Discussion

Prospective analysis quantified lung ventilation in PRISm and COPD populations, indicating MRI's potential for distinction.

Ventilation defect percentage (VDP) in smokers with normal spirometry showed no significant differences compared to COPD or PRISm.
VDP mildly correlated with parametric response map metrics including PRM Emphy % and LAA %.
Prospective, cross-sectional assessment included 90 subjects across three groups using four-dimensional dynamic UTE MRI.
Quantifying ventilation defects with 4D UTE MRI may support early identification of PRISm in at-risk individuals.

Zhang et al. (2025) studied this question.

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