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September 10, 2025PLoS ONEOpen Access

Carbapenemase-encoding genes in critical gram-negative bacteria isolated from ICU patients with infections and/or gastrointestinal carriage, and environmental samples in the amhara National Regional state, Ethiopia

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Authors

MKMizan KinduFMFeleke MogesAAAshenafi Alemu

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Overview

Study reveals diverse carbapenemase-encoding genes in ICU patients and environmental samples, highlighting infection control needs.

Key Points

  • Carbapenem-resistant isolates showed diverse encoding genes, indicating significant infection risks in ICU settings.
  • The predominant gene, bla NDM, was detected in 75.9% of carbapenem-resistant isolates, showcasing a critical public health concern.
  • Singleplex and multiplex PCR were used to analyze the presence of carbapenemase genes in various sources, reinforcing the study's robust methodology.
  • The presence of multiple carbapenemase genes in a notable proportion of isolates emphasizes the urgent need for effective infection control measures.

Cite This Study

Kindu et al. (2025) studied this question.

synapsesocial.com/papers/68c23b8fb210217d64785ca3https://doi.org/10.1371/journal.pone.0330613
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