September 10, 2025Open Access

Tissue geometry and mechanochemical feedback initiate rotational migration in Drosophila

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Rotational migration of epithelial cells is driven by a self-organizing mechanism derived from tissue geometry.
Key findings include a positive feedback loop involving Fat2, enhancing velocity-polarity alignment and sustained rotation.
Experiments combined with theoretical modeling confirmed the role of mechanochemical feedback in initiating rotation.
The study expands existing flocking theories by integrating rigid-body dynamics and tissue geometry in closed epithelial systems.

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Experiments reveal how tissue geometry and Fat2 feedback initiate rotational migration in epithelial cells, suggesting new biophysical mechanisms.

Schwabach et al. (2025) studied this question.

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Experiments reveal how tissue geometry and Fat2 feedback initiate rotational migration in epithelial cells, suggesting new biophysical mechanisms.