September 10, 2025

Quantitative Imaging Markers on HRCT Predict Rapid Progression and Adverse Events of Patients with Idiopathic Inflammatory Myopathies-Related Interstitial Lung Disease.

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Discussion

Retrospective analysis highlights the role of HRCT metrics in predicting rapid progression and adverse events in patients with ASS-ILD and MDA5-ILD.

Ground-glass opacity and consolidation volumes on HRCT independently predicted rapid progression in ASS-ILD patients.
In patients with ASS-ILD, rapid progression occurred in 34.8%, while 44.5% of MDA5-ILD patients experienced similar outcomes.
Elevated imaging markers correlated with increased mortality risk, with a hazard ratio of 4.12 among rapid progressors.
This study demonstrates that baseline HRCT quantification provides actionable insights for risk stratification in ASS and MDA5-ILD patients.

Wang et al. (2025) studied this question.

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Retrospective analysis highlights the role of HRCT metrics in predicting rapid progression and adverse events in patients with ASS-ILD and MDA5-ILD.