September 10, 2025

Disease-Specific and Histological Outcomes of Preoperative TERT Promoter Mutation Detected in Isolation or in Combination with Other Mutations in Thyroid Neoplasms.

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Authors

MCMichael J. Calcaterra ASAlaa Sada EFEsra Karslioglu French

Discussion

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Implication

Retrospective analysis identifies histological outcomes associated with TERT mutation in thyroid neoplasms, suggesting implications for surgical decisions.

Key Points

Preoperative TERT promoter mutations significantly increase the risk of malignancy in thyroid neoplasms.
Patients with isolated TERT mutations show a malignancy rate of 67%, compared to 96% for those with additional mutations.
Histological findings indicate poor differentiation in 33% of thyroid cancers regardless of mutation combination.
Surgical intervention is recommended for isolating TERT mutations to mitigate risks of aggressive disease.

Cite This Study

Calcaterra et al. (2025) studied this question.

synapsesocial.com/papers/68c23b8fb210217d647852e6 https://doi.org/10.1177/10507256251370304

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Implication

Retrospective analysis identifies histological outcomes associated with TERT mutation in thyroid neoplasms, suggesting implications for surgical decisions.

Disease-Specific and Histological Outcomes of Preoperative TERT Promoter Mutation Detected in Isolation or in Combination with Other Mutations in Thyroid Neoplasms.

Discussion

Member takes

Implication

Key Points

Cite This Study

Disease-Specific and Histological Outcomes of Preoperative TERT Promoter Mutation Detected in Isolation or in Combination with Other Mutations in Thyroid Neoplasms.

Discussion

Member takes

Implication

Key Points

Cite This Study

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