September 10, 2025PLoS ONEOpen Access

Cadinapyridine sesquiterpene alkaloids from Artemisia annua and in vitro cytotoxicity and antiplasmodial activities

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Discussion

Assessment reveals isolated alkaloids lacking cytotoxicity in Caco-2 and VERO cells, suggesting further investigation is needed.

Compounds isolated from artemisia annua showed no cytotoxicity against multiple cell lines.
Two new sesquiterpene alkaloids, annuanine A and B, were identified in the study.
The metabolites were characterized using Liquid-Chromatography-Mass Spectrometry and NMR analysis.
Findings may indicate the need for deeper exploration of traditional treatments for malaria.

Fabre et al. (2025) studied this question.

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