Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Open Access

Cardiac Contractility Modulation in Symptomatic Heart Failure With Reduced Ejection Fraction: A Systematic Review and Single-Arm Meta-Analysis

View Full Paper
Ask AI
Bookmark
Share

Authors

RMR MottaCFChristian FukunagaESE. Silva

Discussion

Loading...

Member takes

Overview

Systematic review and single-arm meta-analysis highlights improved functional capacity and quality of life in symptomatic heart failure patients, indicating potential benefits of cardiac contractility modulation.

Key Points

  • CCM therapy significantly improved six-minute walk test distance by an average of 44.96 meters in symptomatic HFrEF patients, enhancing exercise capacity.
  • Patients also experienced a notable reduction in NYHA functional class by an average of −0.89, indicating symptom relief after CCM therapy.
  • Quality of life improved significantly, with MLHFQ scores showing a mean decrease of 11.83 points, demonstrating the therapy’s positive impact on daily living.
  • Structural heart improvements included a 5.96% increase in LVEF and significant reductions in LVESV and LVEDV, supporting enhanced cardiac remodeling.

Cite This Study

Motta et al. (2025) studied this question.

synapsesocial.com/papers/68c23b4ab210217d64784cd5https://doi.org/10.22541/au.175692110.03294929/v1
View Full Paper
Ask AI
Bookmark
Share