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September 10, 2025World Journal of Traditional Chinese MedicineOpen Access

Anoectochilus roxburghii Extract Ameliorates Acute Lung Injury in Mice by Suppressing the Cyclic-GMP-AMP Synthase Stimulator of Interferon Genes Pathway

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Authors

RRRongqin RenYYYulu YanHCHuang Chunqing

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Overview

Experiments demonstrated Anoectochilus roxburghii extract suppresses the cGAS-STING pathway in mice, suggesting new therapies for acute lung injury.

Key Points

  • ARE significantly reduced lung inflammation in an acute lung injury model, revealing its potential as a natural treatment.
  • Analysis showed ARE effectively suppresses cGAS-STING pathway activation with results comparable to the STING inhibitor C-176.
  • The study utilized an LPS-induced ALI mouse model and bone marrow-derived macrophages to assess ARE's anti-inflammatory effects.
  • These results highlight the therapeutic promise of ARE for treating inflammatory diseases linked to cGAS-STING dysregulation.

Cite This Study

Ren et al. (2025) studied this question.

synapsesocial.com/papers/68c23b4ab210217d64784c4fhttps://doi.org/10.4103/wjtcm.wjtcm_11_25
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