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September 10, 2025World Journal of Traditional Chinese MedicineOpen Access

Elucidating the Anti-Atherosclerotic Mechanisms of Sanzi San: An Integrated Approach Using Serum Pharmacochemistry, Network Pharmacology, and Pharmacokinetics

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Authors

HZHuiwen ZhangJWJianye WangYLYanyan Liu

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Overview

Study demonstrates Sanzi San's efficacy against atherosclerosis in ApoE −/− mice, highlighting its pharmacological mechanisms.

Key Points

  • Sanzi San improved aortic lesions in ApoE −/− mice, demonstrating its efficacy against atherosclerosis.
  • Forty-one prototype compounds from Sanzi San were identified, showing potential as bioactive components.
  • Network pharmacology analysis indicated Sanzi San regulates blood vessel diameter, enhancing therapeutic effects.
  • Pharmacokinetic studies confirmed the presence of seven major components in plasma, linking to its anti-atherosclerotic effects.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c23b4ab210217d64784c3fhttps://doi.org/10.4103/wjtcm.wjtcm_49_25
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