September 10, 2025Open Access

Deoxygenation-free Digital Holographic Microscopy discriminates Sickle-Cell Disease in a pilot Colombian cohort via phase and shape metrics

View Full Paper

Ask AI

Bookmark

Authors

Discussion

Pilot study demonstrates digital holographic microscopy distinguishes sickle-cell disease in erythrocytes, suggesting a viable screening tool.

Digital holographic microscopy accurately identifies sickle-cell disease with 97.40% accuracy in a Colombian cohort.
Healthy erythrocytes show a phase difference of 1.72 radians and a circularity index of 0.94.
Sickle-cell disease erythrocytes are characterized by a phase difference of 3.00 radians and a circularity index of 0.70.
These findings indicate that DHM can serve as a complementary method for sickle-cell disease screening in low-resource settings.

Ortega-Sánchez et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark

Pilot study demonstrates digital holographic microscopy distinguishes sickle-cell disease in erythrocytes, suggesting a viable screening tool.