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September 10, 2025npj Metabolic Health and DiseaseOpen Access

Heightened innate immunity may trigger chronic inflammation, fatigue and post-exertional malaise in ME/CFS

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Authors

XCXiaoyu CheARAmit RanjanCGCheng Guo

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Overview

Multi-omics analysis shows exaggerated immune response and systemic inflammation in ME/CFS, suggesting new interventions.

Key Points

  • Chronic inflammation and fatigue are linked to an exaggerated innate immune response in ME/CFS patients.
  • Findings show a disrupted citric acid cycle and metabolic abnormalities, worsening after exercise.
  • Multi-omics profiling was conducted using plasma metabolomic and proteomic data, as well as immune responses to exercise.
  • These insights may facilitate targeted therapeutic strategies for managing chronic fatigue and associated symptoms.

Cite This Study

Che et al. (2025) studied this question.

synapsesocial.com/papers/68c23b4ab210217d64784b76https://doi.org/10.1038/s44324-025-00079-w
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