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September 10, 2025Genome ResearchOpen Access

ScisTree2 enables large-scale inference of cell lineage trees and genotype calling using efficient local search

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Authors

HZHaotian ZhangYZYiming ZhangTGTeng Gao

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Overview

ScisTree2 demonstrates improved accuracy in cell lineage tree inference and genotype calling, highlighting its efficiency in large datasets.

Key Points

  • ScisTree2 achieves better overall accuracy in inferring cell lineage trees from single-cell data, improving research in development, aging, and cancer.
  • It enhances genotype calling based on inferred lineage trees, marking it as a significant advancement in the field.
  • This approach utilizes an efficient local search method for optimal cell lineage tree reconstruction, addressing computational challenges.
  • ScisTree2 is designed to manage datasets involving tens of thousands of cells, proving its scalability and effectiveness.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c23b4ab210217d64784b65https://doi.org/10.1101/gr.280542.125
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