September 10, 2025GeroScienceOpen Access

The associations between playing a musical instrument and grey matter in older adults at risk for dementia: a whole-brain VBM analysis

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Active musicians exhibited significantly increased grey matter density in brain regions associated with music training.
Participants included 61 older adults (aged ≥ 50 years) recruited from a memory clinic, with varied musical experiences.
Voxel-based morphometry analyses assessed grey matter density, while controlling for age and intracranial volume.
The findings highlight potential connections between playing music and brain health, yet cognitive performance showed no significant association.

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Observational analysis revealed higher grey matter in musicians compared to non-musicians, indicating potential cognitive benefits.

Espinosa et al. (2025) studied this question.

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