Genomic frontiers in HIV research: from pathogenesis to curative strategies

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Genomic technologies provide crucial insights into the pathogenesis of HIV and its ability to persist in latent reservoirs.
Next-generation sequencing and CRISPR gene editing offer innovative approaches to targeting viral replication and latency.
RNA-based therapies demonstrate promise for silencing viral gene expression, but clinical translation faces delivery and safety challenges.
Ongoing research aims to overcome these hurdles to develop effective strategies for a functional or complete cure of HIV.

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This review highlights how genomic technologies reveal HIV pathogenesis and latent reservoirs, suggesting new therapeutic strategies.

Tamer A. Addissouky (2025) studied this question.

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