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September 10, 2025Saudi Journal of Medicine

Dual-Target Stereotactic Lesioning in Parkinson’s Disease: Safety and Efficacy Compared to Single-Target Approaches

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Authors

HMHussein Mousa

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Overview

Observational research shows dual-target lesioning improves motor symptoms in Parkinson’s disease while suggesting higher adverse effects compared to single-target approaches.

Key Points

  • Dual-target stereotactic lesioning significantly improved tremor by 85.7%, rigidity by 75.7%, and bradykinesia by 82.4%, compared to single-target approaches.
  • In a cohort of 450 patients, dual-target approaches had higher complication rates, with speech disturbances at 27.1% versus 13.1% in single-target groups.
  • Observational research conducted over 1–2 years compared dual-target and single-target lesioning outcomes in individuals with advanced Parkinson's disease.
  • These findings highlight the need for careful patient selection to maximize benefits of dual-target approaches while minimizing adverse effects.

Cite This Study

Hussein Mousa (2025) studied this question.

synapsesocial.com/papers/68c23b4ab210217d647843b1https://doi.org/10.36348/sjm.2025.v10i08.005
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