September 10, 2025Molecular MetabolismOpen Access

Pde5a deficiency prevents diet-induced obesity via adipose cAMP-PKA activation enhancing fat browning

View Full Paper

Ask AI

Bookmark

Pde5a deficiency significantly reduces obesity and improves metabolic health in mice on a high-fat diet.
The primary evidence shows activation of thermogenic adipose tissue and reduced liver fat in Pde5a knockout models.
Analysis in various Pde5a knockout mice reveals enhanced fat browning through the cAMP-PKA signaling pathway.
These findings suggest potential therapeutic implications for PDE5A inhibition in treating metabolic disorders.

Discussion

No takes yet. Share an insight, caveat, or question.

Pde5a knockout mice exhibit reduced obesity and improved glucose metabolism, highlighting cAMP's role in thermogenesis.

Campolo et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark