Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025

Data from Genetic and Phenotypic Correlates of Clinical Outcomes with Venetoclax in Acute Myeloid Leukemia: The GEN-PHEN-VEN Study

View Full Paper
Ask AI
Bookmark
Share

Authors

CLCurtis A. LachowiezMHMaël HeibligGRGaspar Aspas Requena

Discussion

Loading...

Member takes

Overview

Multicenter analysis shows monocytic differentiation relates to poorer outcomes in AML, indicating potential genetic influences.

Key Points

  • AML patients with monocytic differentiation show increased resistance to venetoclax treatment and higher mortality risk.
  • In NPM1 wild-type AML, monocytic differentiation has a hazard ratio of 1.89 for death, highlighting a significant prognostic factor.
  • This multimodal analysis included data from 678 patients across multiple centers, revealing insights into genetic and phenotypic correlates.
  • The findings suggest that understanding the interplay of genetics and phenotype may guide future therapeutic strategies in AML.

Cite This Study

Lachowiez et al. (2025) studied this question.

synapsesocial.com/papers/68c23b4ab210217d647842e0https://doi.org/10.1158/2643-3230.c.8014455
View Full Paper
Ask AI
Bookmark
Share