September 10, 2025Frontiers in GeneticsOpen Access

Validation of a genome-wide polygenic score for body mass index in South Asians

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Analysis showed high polygenic risk score correlates with increased BMI in South Asian populations, suggesting its predictive value for obesity.

High polygenic risk score (PRS) was associated with increased body mass index (BMI) across three South Asian cohorts.
The analysis included 14,263 individuals, revealing a significant link between PRS and BMI categories.
Validation was performed using a genome-wide PRS model with 2.1 million variants specifically in the South Asian population.
The findings suggest that PRS could serve as an early predictor for overweight and obesity in South Asians.

Menon et al. (2025) studied this question.

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Analysis showed high polygenic risk score correlates with increased BMI in South Asian populations, suggesting its predictive value for obesity.