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September 10, 2025Journal for ImmunoTherapy of CancerOpen Access

m6A-driven transcriptomic rewiring in tumor immune surveillance

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Authors

PMParmanand MalviPBPhilip BallRGRomi Gupta

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Overview

This review explores m6A's role in regulating gene expression and enhancing tumor immune responses, suggesting implications for immunotherapy.

Key Points

  • m6A modifications have a significant impact on mRNA stability and immune response modulation.
  • The review discusses mechanisms of m6A deposition and its effects on antitumor activities with recent advances.
  • Targeting m6A-regulated pathways may enhance the efficacy of existing immunotherapies.
  • Ongoing challenges in developing m6A-targeting drugs are highlighted alongside recent advances in the field.

Cite This Study

Malvi et al. (2025) studied this question.

synapsesocial.com/papers/68c23b08b210217d647838ddhttps://doi.org/10.1136/jitc-2025-012744
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