September 10, 2025Molecular MetabolismOpen Access

Adipose tissue macrophage-derived miR-690 modulates adipocyte precursor cell maintenance and adipogenesis

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Discussion

This study uncovers how microRNA-690 regulates adipocyte precursor cells and influences white adipose tissue health.

In obesity, the lack of miR-690 delivery reduces adipocyte precursor cell functionality, impairing adipogenesis.
Lean mice show that macrophages supply miR-690 to adipocyte precursor cells, supporting healthy WAT expansion.
Targeting the miR-690-Nadk axis in adipocyte precursor cells presents possible therapies for obesity-related metabolic diseases.
Strategies to enhance miR-690 availability could ameliorate unhealthy white adipose tissue expansion.

Rocha et al. (2025) studied this question.

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