September 10, 2025MicroorganismsOpen Access

Study on the Plateau Adaptive Synergistic Mechanism of Rumen Microbiome-Metabolome-Resistome in Tibetan Sheep

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Comparative analysis reveals rumen microbiome and resistome differences in Tibetan and lowland sheep, suggesting adaptive mechanisms.

The study reveals that Tibetan sheep show a significantly higher abundance of Bacteroidetes compared to Hu sheep.
More than 60% of the antibiotic resistance genes were found in higher levels in Hu sheep than in Tibetan sheep.
Metabolomic analysis showed that unique metabolites in Tibetan sheep support their adaptability to the Qinghai–Tibet Plateau.
Microbial flora and metabolites in Tibetan sheep jointly regulate rumen antibiotic resistance genes, highlighting an adaptive mechanism.

Gao et al. (2025) studied this question.

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