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September 10, 2025Pain

Brain levels of the neurotransmitter γ-aminobutyric acid are reduced in people with HIV-related neuropathic pain

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Authors

ASAngelica SandströmMKMinhae KimHarvard UniversityAWAkila WeerasekeraHarvard University

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Implication

Observational analysis reveals decreased GABA and increased temporal summation in people with HIV-related neuropathic pain.

Key Points

  • Lower gaba levels correlate with increased neuropathic pain in people with HIV.
  • Participants with neuropathic pain had decreased gaba levels compared to controls and pain-free individuals.
  • The study utilized 3T magnetic resonance spectroscopy to measure neurotransmitter levels in the brain.
  • Findings suggest a potential link between inhibitory dysfunction and neuropathic pain in HIV patients.

Cite This Study

Sandström et al. (2025) studied this question.

synapsesocial.com/papers/68c23b08b210217d64782dbahttps://doi.org/10.1097/j.pain.0000000000003794
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