September 10, 2025VaccinesOpen Access

Antibody-Dependent Cellular Cytotoxicity Elicited by the Antibodies Against the E120R Protein of African Swine Fever Virus

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Analysis shows anti-pE120R antibodies induce antibody-dependent cellular cytotoxicity in PBMCs, highlighting potential for ASF control.

Anti-pE120R antibodies effectively triggered NK cell-mediated antibody-dependent cellular cytotoxicity.
LDH release assays indicated a significant immune response against HEK293T cells expressing pE120R.
pE120R exhibits high conservation among various ASFV genotypes, suggesting a valuable target for vaccines.
Further in vivo evaluations are necessary to determine the protective immunity offered by the pE120R antigen.

Chen et al. (2025) studied this question.

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