Targeting mitochondrial proteases CLPP and LONP1 via disruption of mitochondrial redox homeostasis induces proteotoxic stress and suppresses tumor progression
Research demonstrates mitochondrial oxidative stress intensifies proteotoxic stress in triple-negative breast cancer, highlighting LONP1 and CLPP as potential therapeutic targets.
Key Points
Inducing mitochondrial oxidative stress significantly suppresses tumor growth in triple-negative breast cancer cells.
Triple-negative breast cancer was 39-fold more sensitive to the mitochondrial-targeted agent, indicating high vulnerability.
Assessment using multiple assays confirmed that excess mitochondrial ROS leads to proteotoxic stress and cell death.
Elevated expression of proteases LONP1 and CLPP correlates with aggressive tumor behavior in breast cancer patients.