September 10, 2025Pharmacognosy MagazineOpen Access

Maprotiline Attenuates Isoflurane-induced Microglial Inflammation

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Maprotiline treatment decreases inflammatory responses in BV-2 microglial cells exposed to isoflurane.
Upon exposure to isoflurane, IL-1β and TNF-α levels significantly rise, which maprotiline effectively reduces.
The mechanism involves inhibition of TLR4 and NF-κB signaling pathways alongside changes in NF-κB nuclear translocation.
Findings suggest that maprotiline can mitigate isoflurane-induced microglial inflammation, supporting its therapeutic use.

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Observational analysis reveals that maprotiline lowers inflammatory cytokines in microglia, indicating potential therapeutic benefits.

Lu et al. (2025) studied this question.

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