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September 10, 2025Open Access

Nutritional Strategies to Prevent Osteopenia of Prematurity: A Narrative Review with a Structured Search

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Authors

DBDaria BorakowskaRPRafał PodgórskiŁOŁukasz Oleksy

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Overview

Narrative review synthesizes evidence on fortified enteral feeding to prevent osteopenia in neonates, suggesting crucial nutritional interventions.

Key Points

  • Early fortified human milk is linked to lower osteopenia of prematurity incidence compared to unfortified feeds.
  • Prolonged parenteral nutrition and delayed enteral advancement elevate the risk of osteopenia of prematurity.
  • Optimizing calcium to phosphorus delivery and using human milk fortifiers can reduce mineral bone disease incidence.
  • Standardized definitions and multicenter protocols are essential for understanding the long-term effects on skeletal health.

Cite This Study

Borakowska et al. (2025) studied this question.

synapsesocial.com/papers/68c23abeb210217d64782181https://doi.org/10.20944/preprints202509.0220.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Status of osteopenia of prematurity in Sub-Himalayan region of India-a single centre experience2025
  2. 2USE OF HUMAN MILK FORTIFIERS IN PRETERM INFANTS – STRATEGIES, BENEFITS AND CLINICAL SIGNIFICANCE: A LITERATURE REVIEW2025
  3. 3Comparative nutritional outcomes in preterm infants and formulation optimization of infant formula: a review2025 · 3 citations
  4. 4Preventing Bronchopulmonary Dysplasia Through Nutrition in Preterm Infants: A Systematic Review of the Literature2025
  5. 5The Significance of Providing the Optimal Micronutrients to the Preterm Low Birth Weight Infants to Prevent Long-Term Health Consequences2025