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September 10, 2025BMC ImmunologyOpen Access

Genetic damage and immune dysregulation in Schistosoma haematobium-infected individuals in Nigeria

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Authors

MOMathew Folaranmi OlaniyanOOOdekunle Bola OdegbemiGIGodfrey Innocent Iyare

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Overview

Cross-sectional analysis shows significant genetic damage and immune dysregulation in urogenital schistosomiasis, indicating urgent health implications.

Key Points

  • Infected individuals exhibited significant genetic damage markers, such as comet tail moment increased to 15.7 from 6.3 in controls.
  • Micronucleus frequency was markedly higher at 8.4 per 1000 cells in the infected group compared to 3.1 in controls, indicating severe genetic impact.
  • IL-4, IL-5, and IL-13 were elevated in infected individuals, reflecting the pronounced Th2 polarization in their immune response.
  • S. haematobium infection was identified as an independent predictor of genetic damage, explaining 73% of the variance in tail moment values.

Cite This Study

Olaniyan et al. (2025) studied this question.

synapsesocial.com/papers/68c23abeb210217d64781848https://doi.org/10.1186/s12865-025-00749-w
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation of the Endemicity and Diagnostic Markers of Urogenital Schistosomiasis Among the “Seldom-Heard Groups in Atiba LGA, Oyo State, Nigeria2025
  2. 2Schistosome Infection is Associated with High-Risk Human Papillomavirus Persistence, Together with Altered Cervicovaginal Microbiota2025
  3. 3Prevalence and associated factors of schistosomiasis among children and adolescents visiting Chitokoloki Mission Hospital of Zambezi District2025
  4. 4Urinary Schistosomiasis on Full Blood Count Among Six Hundred Post-Primary Willing School Children Living in Some Communities Around Kiri Dam, Shelleng Local Government Area, Adamawa State, Nigeria2025
  5. 5Distribution of schistosomes and soil-transmitted helminth infections and their association with growth and nutritional status of School-aged children of the Matta health area in the West region of Cameroon2025