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September 10, 2025Stem Cells

Molecular signature and regulatory network of human umbilical cord mesenchymal stromal cells as a niche for hematopoietic stem cells and progenitors

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Authors

PSPornprapa SrimorkunKSKittisak SuanpanKAKorakot Atjanasuppat

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Overview

Coculture of umbilical cord mesenchymal stromal cells enhances hematopoietic stem cell proliferation, suggesting a niche role.

Key Points

  • UC-MSCs promote UCB-CD34+ cells proliferation, but less effectively maintain their stemness.
  • Transcriptomic analysis revealed important gene modules and a regulatory network linked to UC-MSCs.
  • Significant myeloid lineage commitment in UCB-CD34+ cells was observed on day 3 of culture.
  • Identified hub genes in the PPI network may refine ex vivo culture systems for HSC expansion.

Cite This Study

Srimorkun et al. (2025) studied this question.

synapsesocial.com/papers/68c23abeb210217d647816a4https://doi.org/10.1093/stmcls/sxaf057
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