This research demonstrates how astaxanthin reduces oxidative stress and enhances mitochondrial biogenesis in skeletal muscle, suggesting its therapeutic role under metabolic stress.
Key Points
Astaxanthin significantly alleviates skeletal muscle damage by enhancing mitochondrial biogenesis and reducing oxidative stress.
Mice on a high-fat diet showed improved muscle function after astaxanthin treatment while body weight remained unchanged.
Assessment included histology, quantitative PCR, and biochemical assays to measure oxidative stress and muscle pathology.
Findings suggest astaxanthin could serve as a therapeutic agent for skeletal muscle protection during metabolic stress.