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September 10, 2025Ultrasonics SonochemistryOpen Access

Novel ternary deep eutectic solvent coupled with in-situ-ultrasound synergistic extraction of flavonoids from Epimedium wushanense: machine learning, mechanistic investigation, and antioxidant activity

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Authors

CLCheng LiuJLJie LeiXLXinyu Liu

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Overview

This study demonstrates an advanced method for extracting flavonoids, highlighting the role of deep eutectic solvents and ultrasound.

Key Points

  • The novel ternary deep eutectic solvent achieved a total flavonoids yield of 26.39 mg/g, outperforming conventional methods.
  • Using the Response surface methodology-artificial neural network-genetic algorithm, optimal extraction conditions were identified.
  • Phytochemical profiling via UHPLC-Q-TOF-MS confirmed the presence of 9 flavonoids in the extract, emphasizing its potential bioactivity.
  • The method promotes eco-friendly extraction technologies, supporting sustainable utilization of medicinal plants.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68c23a74b210217d64780ff7https://doi.org/10.1016/j.ultsonch.2025.107547
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